Giles founded and chairs Proboscis' board of directors. He leads Proboscis' research programme (the SoMa think tank) as well as directing major projects and initiatives such as Social Tapestries, Urban Tapestries and Mapping Perception.
Giles founded and edited COIL journal of the moving image, co-edited Ghost Stories by Pavel Büchler, conceived the DIFFUSION eBook format and the eBook Generator and designed the latest StoryCubes format.
Between 1998 and 2002 Giles worked at the Royal College of Art, first in the Computer Related Design Research Studio (1998-2001), and latterly as a Research Fellow in the School of Communications. Giles is currently Associate Research Fellow to MEDIA@LSE, the media and communications department at the London School of Economics and Political Science.