Before coming to Georgia Tech in 1999, Murray was a Senior Research Scientist in the Center for Educational Computing Initiatives at MIT, where she taught humanities and led advanced interactive design projects since 1971. She is well known as an early developer of humanities computing applications, a seminal theorist of digital media, and an advocate of new educational programs in digital media.
Janet Murray design projects include a digital edition of the Warner Brothers classic, Casablanca. In addition she directs an eTV Prototyping Group, which has worked on interactive television applications for PBS, ABC, MTV, Turner, and other networks. She also works extensively as a member of Georgia Tech's Experimental Game Lab and is an advisor to Georgia Tech's Mobile Technology Group.