She is interested in how literacy values and practices in digital environments shape, and have been shaped by historic, economic, social, cultural, material, educational, and personal factors, computer uses in educational settings.
Selfe is the first woman and the first English teacher ever to receive the EDUCOM Medal for innovative computer use in higher education. She has authored or edited a number of works on digital technology, both alone and in collaboration with colleagues. Along with Scott DeWitt, she is the Director of OSU's annual Digital Media and Composition (DMAC) summer institute.